New drug candidate prolongs the lives of pancreatic cancer patients

Innovative Tel Aviv University research holds promise for a broad range of human disease Every year, 42,000 Americans are diagnosed with pancreatic cancer. Few live very long, and less than 5% are still alive five years after diagnosis. There's new hope, though, from the lab of Prof. Yoel Kloog, dean of Tel Aviv University's Faculty of Life Sciences. His drug compound Salirasib has shown positive results against pancreatic cancer and recently passed Phase I/II clinical trials. The drug, given in combination with gemcitabine, the standard drug used to combat pancreatic cancer, almost doubled the life expectancy of those who received it. "In our study, the mean survival of pancreatic cancer patients was 10.8 months –– better by far than the 6.2 months with gemcitabine alone," says Prof. Kloog, who recently presented the results to a meeting of the American Society of Clinical Oncology. His basic research offers the promise of a weapon to attack a broader range of mankind's most prevalent diseases, including lung, prostate and breast cancers as well as diabetes.

Blocking the Ras protein

Salirasib works by inhibiting a protein called Ras, which is known to be abnormally activated in one-third of human cancers. In cancer of the pancreas, mutant forms of Ras are found in up to 90% of all tumors. Salirasib's basic component, FTS, works to block the formation of cancer-promoting Ras nanoclusters, thus blocking a cascade of biochemical signals known as the "Ras signaling pathway" that allow Ras to wreak havoc on the body. Early in the 1990s, many drug developers chased after a mechanism to inhibit Ras by targeting enzymes that modify it, but they were unsuccessful. "The major developers gave up, claiming Ras is not targetable," says Prof. Kloog, "but our concept takes a different approach. Now that we've shown it works in human subjects, I am definitely excited — no doubt about it." Prof. Kloog developed the Ras antagonist more than 15 years ago.

No toxic side effects

In the latest study, researchers tested for both toxicity and effectiveness. They gave 19 patients with advanced pancreatic cancer daily doses of salirasib along with a standard gemcitabine regimen. Salirasib was well tolerated by the patients, and they surpassed on average the number of months they would have lived on gentamiacine alone. There were no toxic side effects, such as heart or lung ailments. Tumor biopsies showed a significant reduction in Ras levels, suggesting that the drug is inhibiting the action of Ras in the tumor itself. For this study, Salirasib was licensed by Concordia Pharmaceuticals, which collaborated with the Memorial Sloan Kettering Cancer Center, Johns Hopkins, the M.D. Anderson Cancer Center and other institutes in the United States. If Phase II/III trials are successful, Prof. Kloog's drug will be the first successful Ras antagonist known to medical science. Salirabib could be medically available in as little as two years...read more

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FDA Tells Patients to Stick With Diabetes Drug Linked to Cancer

July 1 (HealthDay News) -- Despite recent studies suggesting that the injected diabetes drug Lantus (insulin glargine) might boost cancer risk, the U.S. Food and Drug Administration on Wednesday urged patients who are on the medication to continue using it. Three of four studies published last Friday in Diabetologia showed a potential link between Lantus -- an insulin analogue made by French drug company Sanofi-aventis -- and increased risks for various tumor types.

But, "the duration of patient follow-up in all four studies was shorter than what is generally considered necessary to evaluate for cancer risk from drug exposure," the FDA said in its first comment on the issue. "Further, inconsistencies in findings within and across individual studies raise concerns as to whether an association between the use of insulin glargine and cancer truly exists." The agency also believes that differences in the various types of patients selected for each study may have swayed the results...read more

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This Artificial Insulin Causes Cancer?

Shaky data from European studies suggest that the long-acting insulin product Lantus might slightly increase cancer risk in people with type 2 diabetes. People should not stop taking Lantus because of this finding, says the FDA. A wide range of diabetes organizations -- and the editors of the journal that published the new findings -- agree that there's no cause for alarm.

"Do not stop taking your insulin. There is no immediate danger if you currently use or previously used [Lantus]," says the American Diabetes Association...read more

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4 Reasons to Eat Beans for Diabetics

They often get a bad rap for causing indigestion and flatulence, but the health benefits of beans (and other legumes, such as lentils and chickpeas) make them a stellar choice in a healthful diet. Beans are:

1. An excellent source of vegetarian protein, providing six to seven grams per 1/2 cup serving.
2. High in folic acid, which may help to protect against cancers of the lung, colon, and cervix, and prevent birth defects.
3. A great source of fiber, dishing up 25-30% of the Daily Value of dietary fiber, 75% of which is insoluble - the type that reduces the risk of colon cancer.
4. A low-glycemic- index food, making them a good option for diabetics.

In addition, most varieties are inexpensive and versatile. I recommend 1-2 servings of beans and legumes per day - easy to do if you swap out meat for beans in salads and sandwiches, and make hummus or bean dip part of an afternoon snack. And if stomach upset is a concern, you can improve the quality and digestibility of beans by consuming them with grains such as brown rice, which provide a complimentary protein profile. Discarding the soaking and cooking water when using dry beans may also help reduce flatulence.

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Food for Men No. 4: Broccoli

While virtually all vegetables deserve a place on the superfoods list, cruciferous vegetables like broccoli are helpful in the prevention of heart disease and cancer. It's loaded with vitamin C, beta-carotene, potassium, and a phytochemical called sulphoraphane, which has strong anticancer (prostate and colon) properties. A recent Harvard study found that participants who had five servings a week of cruciferious vegetables were half as likely as others to develop bladder cancer, a cancer that affects two to three times as many men as women. This super-nutritious green vegetable may also help lower levels of homocycteine, an amino acid associated with increased risk of heart disease and stroke.

Don't care for broccoli? Go for other cruciferous choices like cabbage, bok choy, shredded broccoli slaw, cabbage, cauliflower, or Brussels sprouts. And did you ever wonder where the term "cruciferous" originates? "It is not because they are crunchy vegetables, but when the buds from this group of vegetables sprouts, their leaves form a cross like a crucifix," explains Denver dietitian Mary Lee Chin, MS, RD.

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Food for Men No. 3: Fatty Fish

No list of superfoods would be complete without the healthy fat, omega-3 fatty acids. These polyunsaturated fats are the preferred form of fats in your diet for many reasons. They can benefit the heart, circulation, and immune system and reduce the risk for prostate cancer, among other things. "Omega-3 fatty acids are potent anti-inflammatory foods that can help lower triglyceride [blood fat] levels, reduce aches and pains in athletes, and offer relief with certain kinds of arthritis,"
says Bauer.

Fatty fish (salmon, sardines, tuna, mackerel, herring) are the richest sources of omega-3 fatty acids. In fact the American Heart Association recommends that everyone eat fish twice weekly. You can also get omega-3s in plant-based foods, like flaxseed,
walnuts, soy, canola oil, and fortified products such as eggs. But there are other good reasons to eat fish. "Fatty fish are also a good source of vitamin D, a nutrient that tends to be deficient in our diets and [which] in adequate supply can help prevent cancer, type 2 diabetes, high blood pressure and
bone disease," says Bauer.

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30 Ways To Prevent and/or Reverse An Acidic Cancerous Condition

About 1.3 million Americans are diagnosed with a cancerous acidic condition each year and about 500,000 die from this acidic dis-ease. Some cancerous acidic conditions claim more lives than others, and there are things you can do to stop doing cancer. Here are the four deadliest acidic cancerous conditions caused by acidic lifestyle and diet and how you can prevent them:

1) Acidic Cancerous Lungs. Acidic cancerous lungs is the leading cause of cancer death in America and will claim more than 157,000 lives this year. More than 80 percent of acidic cancerous lungs are linked to smoking acidic fermented with sugar coated cigarettes. Even if you don't smoke, but live or work with smokers, your risk rises due to second-hand smoke. Don't smoke and encourage the smokers in your life to quit this acidic sugar addictive habit.

2) Acidic Cancerous Colon. Acidic Cancerous colon will claim the lives of about 57,000 Americans this year, but it is a highly curable cancerous condition if caught early, using live and dried blood cell analysis. Since high acidic animal protein, dairy and saturated/trans fat diets and sedentary lifestyles double the risk of colon cancer, switch to the pH Miracle Lifestyle and diet rich in green fruits, green vegetables, healthy alkalizing oils from hemp, olive, avocado, live sprouts, alkaline water, liberal amounts of mineral salts, alkaline nutritional supplements, sunshine (Vitamin D) or supplemental D3 at 50,000 I.U.'s daily and added alkaline exercise for 1 hour daily.

3) Acidic Cancerous Breasts. Although 40,000 women and 5,000 men will die from acidic cancerous breasts this year, 85 percent of breast cancer patients are alive five years after diagnosis. The five-year survival rate rises to 95 percent if the cancer is localized, so early detection and an alkaline pH Miracle Lifestyle and Diet is essential. The major cause of breast cancer is dairy products and bread. Eliminate all acidic dairy products and bread.

4) Acidic Cancerous Prostate. Acidic cancerous Prostate is the most common acidic cancerous condition in men over the age of 70 and will claim the lives of 29,000 Americans this year. Dr. Robert O. Young, Director of Research at The pH Miracle Living Center states, "a cancerous prostate is caused by an acidic lifestyle and diet which is triggered with a diet that is high is acidic animal protein, dairy products, saturated fat and lack of daily exercise. A cancerous Prostate is preventable and if detected early through live and dried blood analysis is 100% reversible."...more

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Diabetes: Alcohol, Cigarettes and Diabetes Up Colorectal Cancer Risk

It's been known for some time that obesity and eating lots of red meat can raise the risk of colorectal cancer, but new research sheds light on other lifestyle factors that increase risk. Drinking alcohol, smoking cigarettes and having diabetes also play a major role in determining who is going to develop colorectal cancer, study findings show.

And although exercise seemed to help ward off colorectal cancer, eating lots of fruits and vegetables didn't, according to researchers at The George Institute for International Health in Australia. "Most people probably know that being overweight and having poor dietary habits are risk factors for the disease," said study author Rachel Huxley, an associate professor at The George Institute. "But most are probably unaware that other lifestyle risk factors such as alcohol consumption, cigarette smoking and diabetes are also important culprits," she said in a news release from the institute.

Not counting skin cancers, colorectal cancer is the third most common cancer among U.S. adults, according to the American Cancer Society. An estimated 50,000 people will die of colorectal cancer this year in the United States. Worldwide, about one million new cases of colorectal cancer are diagnosed annually and more than half a million people die, according to background information in the news release.

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Cancer: Cardiovascular Fitness Not Affected By Cancer Treatment?

The cardiovascular fitness level of cancer survivors is not affected by many standard cancer therapies, say researchers from Georgetown University Medical Cancer. That is the finding of a new observational study to be presented today at the American College of Sports Medicine in Seattle.

"We know physical activity is a critical component of cancer survivorship, both during and after cancer treatment," says Jennifer LeMoine, PhD, a post-doctoral research fellow with training in exercise physiology at GUMC's Lombardi Comprehensive Cancer Center. "In order to ... for full story -

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Cancer: Preventing Cancer Supplements and Nutrition

Preventing Cancer Part 1: Supplements

We all need essential fatty acids for optimum health, but most
Americans consume far too many omega-6 fatty acids (mainly from vegetable oils), and not enough omega-3 fatty acids (found in oily fish, walnuts and freshly ground flaxseed). This imbalance can lead to an increased risk of heart disease, inflammatory conditions, cancer and other health concerns.

While eating several servings of oily fish (I prefer wild Alaskan salmon and sardines) per week is a start, you may want to consider fish oil supplements, especially if you don't enjoy fish. Available in liquid or capsule forms, fish oil is effective at helping to reduce blood pressure, is beneficial to the nervous system, and can even help alleviate mild to moderate depression. Omega-3 fatty acids may also help support the health of breast tissue by maintaining healthy breast cells, a positive note for women with a family history of breast cancer. Look for capsules or oil that are certified free of contaminants, and begin with small daily doses, building up to the recommended amount.

Preventing Cancer Part 2: Nutrition
Yesterday's Daily Tip focused on cancer and supplements; today we look at nutrition and its relationship to cancer. A healthy diet can help the body in its efforts to heal itself, and in some cases, particular foods can lessen the risks of serious illness. To help reduce your risk of some types of cancer, try the following:

1. Avoid polyunsaturated vegetable oils, margarine, vegetable shortening, all partially hydrogenated oils, and all foods that might contain trans-fatty acids (such as deep-fried foods).
2. Increase omega-3 fatty acids by eating more cold water oily fish, freshly ground flaxseeds, and walnuts.
3. Reduce consumption of animal foods and try to replace them with vegetable proteins such as whole soy products.
4. Use hormone-free, organically produced products whenever possible.
5. Eat plenty of fresh fruits and vegetables.
6. Eat shiitake, enokitake, maitake, and oyster mushrooms frequently.
7. Drink green tea daily.
From: Dr Weil

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Cancer: Karsinogenik compound is a compound that can cause cancer

Karsinogenik compound is a compound that can cause cancer. Most of the compound in karsinogenik food into the body is in the form of prokarsinogenik. Furthermore, by the phase I enzyme produced by liver, prokarsinogenik compound is a compound cut karsinogenik that can damage cells or DNA memutasikan. This is the initiation stage of cancer cell growth. Four prokarsinogenik compound which is found in food are:

(1) MIKOTOKSIN, poison or toxin that is produced by kapang (mushroom), particularly Aspergillus, Penicillium, and Fusarium.
(2) NITROSAMIN and NITROSAMIDA, namely N-nitroso compound in the meat of the fried, the meat dried (WH: jerked meat), meat is preserved with the addition of nitrate or nitrit, and cigarette smoke.
(3) POLISIKLIK Aromatic hydrocarbons (PAH) that can form on the meat grilled with charcoal coals or wood oil.
(4) Product PIROLISIS amino acid, such as aromatic amino acid heterosiklik, resulting from combustion is not perfect concoction for a fish or meat.

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Cancer: Strawberry contains fitokimia called etlagic acid as antikarsinogen and antimutagen

Besides vitamin, strawberry also contains fitokimia compound called etlagic acid, a compound that is potentially fenol as antikarsinogen and antimutagen. Compound karsinogen that trigger the occurrence of cancer is prevalent in our environment, whether that comes from food and non food. Therefore, as we already provide with a lot of dm consume food containing the compound antikarsinogen, such as strawberry.

Ellagic acid is a natural compound fenolik found on several plant families, such as `Rosaceae, Fagaceae, Saxifragaceae, Cunomirutceae and Myrotharnnaceae. Types of plants and the many family RosncPae contain ellagic acid, among strawberry and apple. In the strawberry, the compound found in the seeds, leaves, fruit and meat. Gynecology ettagic acid in strawberry fruit in the range of 0.43 - 4.64 mg per gram dry weight. United States is the country's most diligent researching property of ellagic acid as the most they consume a lot of strawberry in the world.

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Colon Cancer May Occur If Less Sports

Colon cancer may occur if we are less sports, fibrous food.

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Gallstone If Not Treated Can Cause Cancer

Please read the original article from the bottom of the Dr Lai Chiu-Nan, how to remove gall stones without surgery and the cost is very cheap and does not damage our bodies. I have followed the advice he and gall stone out without any operation. (This is not detoxinasi, but as cleaning the stomach). USG results I was full of gall stones,after this treatment I request USG back as evidence.In fact true ... my gall bladder is empty ... Somehow I his speech to thank Dr Lai Chiu-Nan, but I just want to sharing experiences appropriate intention Dr Lai Chiu-Nan to share experience...read more

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Curcumin is One of The Best Used To Treat Breast Cancer

Now experts have been examining the health benefits of turmeric. Based on the actual substance of the turmeric can prevent and treat cancer in this turmeric should be consumed every day. But not every turmeric is used for the treatment of cancer, which is white turmeric. Curcumin and breast cancer is one of the areas of research that has been done in the year 10-an. Neutraceuticals interest has grown phenomenally by scientists around the world because they have found a powerful way only a few properties of spices and other food can.

Disease protection

Two groups of people who jump directly to the French mind and heart is the prevention of their conditions, although they eat a high fat food, which was partly down to the resveratrol and the low incidence of Alzheimer's Disease among Indian nations that have come down to turmeric, curcumin, especially...read more this article

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Lobular Breast Cancer is One That Has Already Infiltrated Beyond The Membrane

If a person is exposed to disease and cancer can be detected in the early stages then it's likely to be cured. Because if the cancer has spread to other body of the network will occur, and complications less likely to be cured. Cancer certainly will be easier to detect and treat it if one entity with one simple cause. But it does not. Experts agree that there is actually some 200 different diseases that can be called a cancer. Lobular breast cancer is one of them.

From breast cancer is one of the oldest and most recognized types of cancer. In the case of how the cells appear under the microscope, you can categorize the various types of breast cancer that is as follows: ductal, lobular, medullary, mucinous, tubular breast cancer.

Hormonal factors involved in the physiology of disease has been studied by doctors for over 100 years. But still the most common affecting women. For us to have a better understanding of breast cancer, it is very important for us to know the basic chest. Consists of glands that make breast milk, called lobules, small tubes that carry milk from the lobules to the nipples is called ducts, blood vessels, lymph vessels, connective and fatty tissues...read more this article

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Early Detection Breast Cancer with Treatment Center

Breast cancer can be treated effectively if it is detected early enough. Some 95 percent of breast cancer patients were found by their own when he notices a lump. In some countries women have been conscious to be examined if there is a breast lump. With the knowledge of breast cancer increased the breast cancer can be detected early and are likely to be cured before spreading to other body parts. Therefore in the cities there was a clinic or hospital that can detect early breast cancer.

The cure rate for breast cancer can be increased if all the women made a routine of monthly self-exam, and then consult with your doctor immediately if they find the least indication of the material or bruised. Lumps as the most tame, but the most important of which can be identified violent without delay. Almost every town has a breast cancer treatment center that will provide services for patients and the diagnosis of various breast cancer treatment option them...read more

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List of Drugs Recommended for Tackling Breast Cancer

Ways to treat cancer can be done with the surgery, radiation and chemotherapy. But not all people affected by cancer in this breast cancer therapy as you want to do over because people fear the side effects that occur. Therefore health experts trying to search for cancer drugs, among others. Promising new method to provide a focus on anticancer drugs that are appropriate for cancer and improve immune system to fend off cancer. There is a list of drugs for breast cancer, each with its own pros and drug cons. Anticancer drugs have unpleasant side effects because most of the target all the cells divide rapidly, including the normal.

Side effects including nausea, vomiting, and loss of hair. X-rays also have side effects because their bodies go through the kill healthy cells that are located on the road with the cancer cells. Fortunately, now there are a number of lists of drugs for breast cancer. Each is tailored to the patient's severity. Type of drug that will make the patient different from other breast cancer patients because each person is different...read more

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Full Stage Breast Self Examination: View, Squeeze, Palpate, Palpate Oxter

Will be better prepared if a special note book to record your examination results, as well as conditions and changes in your breasts from time to time. When you need to complete with illustrations to clarify the image location aberration found.

Complete breast self examination is divided into several stages:

1. View
Do not use the top of the clothes. Stand in front of the mirror with the second depending arm loose, in the light of the room. Watch your breast:

* What is the shape and size right and left symmetrical?
* What shapes up / set?
* What is the direction putingnya straight ahead? Or change direction?
* Is interested in the hilt?
* What stalk / skin abrasions that have?
* Does the skin appear reddish? Kebiruan? Black?
* Does the skin look thick with broad pore-pore (such as orange peel)?
* Is the surface of the skin smooth, not the contraction / basin?

Repeat all the above observation with the position of both hands straight up. When finished, repeat again with both hands observed in the waist, chest drawn up, both drawn to the back of the elbow. All observations aimed to know the tumor is located close to the skin.

2. Squeeze
With both hands, massage the breast from the soft edge to the hilt, to have to know the case out of the fluid nipple (should not have, unless you're breastfeeding).

3. Palpate
Now sleep in the recumbent on the bed to check the breast one by one. To check the left breast, place a thin pillow under the left shoulder, left arm are in the open top on the side of the head or placed under the head.

Use the fourth finger of right hand to palpate breast meetings. Palpation performed with the movement to play (such as making small circles), from the edge to the breast nipple. After that slide the position next to the little finger, and do more movement from the edge to play until the breast nipple. Do continue sequentially until the entire breast is examined. To facilitate movement, you can use a lotion or soap.

Movement can also play from the nipple, the width of a circle to the edge breast or vertically up and down from the left edge to the far right edge. It is important, the entire breast area must be thoroughly palpate, no that does not handle.

Note that each movement must be made to play with the strength of the pressure is different, with at least three kinds of pressure. First done with light pressure to feel the benjolan near the skin surface, the second with medium pressure to feel the benjolan in the middle of the network breast, the third with pressure strong enough to feel the bumps in the breast base, near the sternum / rib.

Once finished with the left breast, move pillow and arm position, perform a breast examination on the right using the left hand fourth finger.

Then repeat the palpability as 3 points, but in standing position. To make things easier, while a bath can be done, when the body washed with soap.

4. Palpate oxter
Then grapple armpit and the area around the breast to determine the existence of a gravel suspected child sebar cancer.

When in breast self examination, you find a deviation (eg, gravel, small any), check to see a doctor immediately. Do not be afraid and do not delay anymore. Because breast cancer is found in the early stages and treated properly can recover completely!..more

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Best Time to Check The Condition of Breast

Breast have the parts (the environment) be touched if you feel different. Quite to the top side (near the armpit) tend to have a large clump-clotted. The bottom of the breast feels like a carpet of sand or gravel. Are below the nipple feels like a set of seeds is large. Sometimes there is also a lump resembling a bowl. This situation can be different for each woman.

At the initial stage, will be enough to help if you create a "map breast environment," compared to the examination from month to month.

The most important is how the taste of your own breast conditions. Is there something that feels different than the environment? For example, in the area "big lump" feels a little benjolan of green beans? Or in the area "overlay sand" feel there "gravel" is quite large? Or have changes in breast condition compared to the previous examination? That can be detected with all check their own breasts.

Sulitkah perform breast self examination is? Not at all. Should be done a week after menstruasi, when the condition of breast and soft loose, making it easier for palpability. For women who are experiencing menopause may be done at any time, the routine of every month.

Will be better prepared if a special note book to record your examination results, as well as conditions and changes in your breasts from time to time. When you need to complete with illustrations to clarify the image location aberration found.

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